1. Immunotherapy
Immunotherapy is a type of treatment that uses the body's immune system to fight cancer. It involves the use of drugs that stimulate the immune system or antibodies that target cancer cells. One example of immunotherapy for Large B-Cell Lymphoma is the use of checkpoint inhibitors, which block proteins that prevent immune cells from attacking cancer cells. Immunotherapy can be used as a first-line treatment or after other treatments have been tried. It has shown promising results in improving outcomes for patients with Large B-Cell Lymphoma.
2. Targeted Therapy
Targeted therapy is a type of treatment that targets specific genes, proteins, or pathways involved in the growth and survival of cancer cells. It works by interfering with the signals that cancer cells need to divide and grow. One example of targeted therapy for Large B-Cell Lymphoma is the use of monoclonal antibodies, which bind to specific proteins on cancer cells and block their growth. Targeted therapy can be used alone or in combination with other treatments. It has shown promise in improving outcomes for patients with Large B-Cell Lymphoma.
3. CAR T-Cell Therapy
CAR T-cell therapy is a type of immunotherapy that involves modifying a patient's own T cells to recognize and attack cancer cells. It works by collecting the patient's T cells, genetically modifying them to express chimeric antigen receptors (CARs), and then reintroducing them into the patient's body. These CAR T cells can recognize and destroy cancer cells more effectively. CAR T-cell therapy has shown remarkable results in treating relapsed or refractory Large B-Cell Lymphoma, with high response rates and durable remissions. However, it is currently limited to certain specialized centers and may have significant side effects.
4. Stem Cell Transplantation
Stem cell transplantation, also known as bone marrow transplantation, is a procedure that replaces damaged or destroyed bone marrow with healthy stem cells. It allows high-dose chemotherapy or radiation therapy to be given to kill cancer cells and then replaces the damaged marrow with healthy cells. Stem cell transplantation can be used as a consolidation therapy after initial treatment to further reduce the risk of relapse. It can also be used for patients who have relapsed or refractory disease. There are two main types of stem cell transplantation: autologous transplantation, which uses the patient's own stem cells, and allogeneic transplantation, which uses stem cells from a donor. The choice of transplantation depends on various factors, including the patient's age, overall health, and availability of a suitable donor.