Understanding Spinraza
Spinraza is an FDA-approved medication designed to treat spinal muscular atrophy (SMA), a genetic disorder characterized by weakness and wasting in the muscles. It works by increasing the levels of survival motor neuron (SMN) protein, which is critical for the survival of motor neurons. Spinraza is administered via intrathecal injection, directly into the cerebrospinal fluid.
Preparing for Administration
Before administering Spinraza, healthcare providers must gather necessary equipment including syringes, needles, antiseptic wipes, and a spinal needle. Patients should be positioned appropriately, typically in a seated position or lying on their side with knees drawn toward the chest. It is crucial to check the medication for clarity and expiration date. Do not use the medication if it appears cloudy or has particles.
The Administration Procedure
The administration begins with cleaning the injection site on the lower back with antiseptic wipes to prevent infection. Once the site is dry, the clinician will insert the spinal needle into the subarachnoid space. Inject the Spinraza slowly through the syringe while monitoring the patient for any adverse reactions. After the injection, the needle is carefully removed, and pressure is applied to the injection site to reduce bleeding.
Post-Administration Care
After the Spinraza injection, patients are usually monitored for around one hour for any immediate side effects such as headache or dizziness. Patients should be instructed to lie flat for a period of time post-injection to reduce the risk of headache. Follow-up appointments should be scheduled as per the treatment plan to assess the patient's response to the medication.
Managing Potential Side Effects
Some common side effects of Spinraza include headache, back pain, and gastrointestinal issues. Patients should be educated on how to manage mild side effects with over-the-counter medications and rest. In case of severe side effects, prompt medical attention is necessary.
Storing Spinraza
Spinraza should be stored in the refrigerator between 2°C to 8°C (36°F to 46°F). Avoid freezing the medication and keep it away from light. It is important to follow storage recommendations to maintain the efficacy of the medication.
Conclusion
Administering Spinraza requires careful preparation, execution, and follow-up to ensure the safety and effectiveness of the treatment for spinal muscular atrophy. By following the detailed steps outlined in this article, healthcare providers can enhance patient outcomes and minimize risks associated with the administration of this vital medication.