Understanding Heart Failure
Heart failure is a chronic condition where the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs. It can result from various factors, including coronary artery disease, high blood pressure, and previous heart attacks. Symptoms of heart failure may include shortness of breath, fatigue, swollen legs, and rapid heartbeat.
What is Entresto?
Entresto is a prescription medication that contains the combination of sacubitril and valsartan. It is specifically used to treat heart failure with reduced ejection fraction (HFrEF). The medication works by helping the heart to pump more efficiently and relieving symptoms associated with heart failure.
Mechanism of Action
Entresto works by inhibiting the neprylisin enzyme, which leads to increased levels of natural substances that relax blood vessels. By also blocking angiotensin II effects as a receptor blocker, it helps to decrease blood pressure and reduce strain on the heart. This dual mechanism targets the underlying issues of fluid retention and arterial stiffness associated with heart failure.
Dosage and Administration
The typical starting dose of Entresto is usually 49/51 mg twice daily, which may be adjusted based on tolerance and response. It is essential to follow the healthcare provider's instructions regarding dosage adjustments. Entresto can be taken with or without food, but it is crucial not to crush or chew the tablets.
Benefits of Entresto for Heart Failure Patients
Entresto has been shown to reduce the risk of cardiovascular death and hospitalization for heart failure. Patients may experience improved symptoms, enhanced quality of life, and potential prolongation of life. The medication's ability to improve heart function may lead to fewer complications and better overall health.
Potential Side Effects
Common side effects of Entresto include low blood pressure, elevated blood potassium levels, and kidney problems. Patients may also experience dizziness, fatigue, or increased urination. It's important to report any severe side effects or signs of allergic reactions to a healthcare provider immediately.
Considerations and Precautions
Before starting Entresto, patients should inform their doctor about any other medications they are taking, especially diuretics or ACE inhibitors. It's crucial to avoid the use of ACE inhibitors within 36 hours of taking Entresto. Regular monitoring of blood pressure and kidney function is recommended while on this medication.
Patient Education and Support
Patients should be educated about the importance of adhering to their treatment regimen and understanding how Entresto works. Support groups and patient education programs can help individuals cope with heart failure and medication management. Encouraging routine follow-ups with healthcare providers is essential for optimal management of heart failure.
Lifestyle Changes to Complement Treatment
In addition to medication, adopting a heart-healthy lifestyle is crucial for managing heart failure. Patients are encouraged to engage in regular physical activity, maintain a balanced diet low in sodium, and manage stress effectively. Quitting smoking and limiting alcohol intake can also improve heart health and overall wellbeing.