Understanding Plaque Psoriasis
Plaque psoriasis is a chronic autoimmune condition characterized by the rapid growth of skin cells, leading to thick, red, scaly patches on the skin. While the exact cause of plaque psoriasis is not fully understood, it is believed to be related to an immune system dysfunction that triggers inflammation and skin cell production. Symptoms of plaque psoriasis can include dry, cracked skin that may bleed, itching, and soreness, as well as thickened, pitted, or ridged nails, and swollen and stiff joints.
What is Skyrizi?
Skyrizi, generically known as risankizumab, is a monoclonal antibody that targets a specific protein in the immune system called interleukin-23 (IL-23). By inhibiting IL-23, Skyrizi reduces inflammation and helps to control the rapid cell growth that leads to the formation of plaques in psoriasis. Skyrizi is FDA-approved for the treatment of adult patients with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
Benefits of Using Skyrizi
Skyrizi is not only effective in reducing the severity of psoriasis, but it can also offer long-lasting remission compared to traditional treatments. Clinical studies have shown that Skyrizi can clear skin in a significant number of patients with moderate to severe plaque psoriasis after the first few doses. In addition, many patients report improvements in quality of life, including reduced itching, less embarrassment due to visible lesions, and fewer flare-ups.
How to Administer Skyrizi
Skyrizi is administered via subcutaneous injection. It can be injected into the abdomen, thigh, or upper arm. The initial dosing schedule typically involves two injections at weeks 0 and 4, followed by a maintenance dose of one injection every 12 weeks. It's important to follow your healthcare provider's instructions on how to properly administer Skyrizi, including proper storage and preparation of the injection.
Important Considerations Before Using Skyrizi
Prior to starting Skyrizi, patients should discuss their complete medical history with their healthcare provider, especially any history of infections, hepatitis B, tuberculosis, and any other ongoing medical conditions. Regular monitoring may be required to check for potential side effects and to ensure the treatment is effective. Patients should also inform their healthcare provider about any medications or supplements they are currently using to avoid potential interactions.
Possible Side Effects of Skyrizi
While Skyrizi is generally well-tolerated, some potential side effects may include injection site reactions, headaches, fatigue, and an increased risk of infections. Patients should be aware of signs of serious infections, such as fever, chills, or persistent cough, and report any concerning symptoms to their healthcare provider immediately. Long-term safety data is still being collected, so ongoing communication with a healthcare provider is crucial.
Living with Plaque Psoriasis on Skyrizi
For many patients, Skyrizi can lead to significant clearing of plaques and an overall improvement in skin health, boosting confidence and reducing social anxiety. It is essential for patients to stay engaged with their healthcare team and inform them of any changes in symptoms or new side effects. Maintaining a healthy lifestyle, including a balanced diet and regular exercise, can further enhance treatment effects and improve overall well-being.
Follow-Up Care and Monitoring
Regular follow-up appointments with a dermatologist or healthcare provider are essential to monitor the effectiveness of Skyrizi and make any necessary adjustments in treatment. Blood tests may be required periodically to check for side effects and assess overall health. Patients should be proactive in addressing any concerns during their visits and adhere to the scheduled maintenance dosing.