What are some pre-HIV medications?

Pre-exposure prophylaxis (PrEP) medications are a crucial aspect of preventing HIV transmission. These medications are taken by individuals who are at high risk of contracting HIV but are HIV-negative. By taking pre-HIV medications, these individuals can greatly reduce their chances of becoming infected with the virus. This article explores some of the commonly used pre-HIV medications and their effectiveness.

1. Truvada

Truvada is one of the most widely prescribed pre-HIV medications. It contains two drugs, tenofovir disoproxil fumarate and emtricitabine. Truvada is taken once daily as a pill and is highly effective in preventing HIV infection. It works by blocking the enzyme called reverse transcriptase, which is necessary for HIV to replicate in the body. Clinical studies have shown that Truvada can reduce the risk of HIV transmission by more than 90% when taken consistently.

2. Descovy

Descovy is another pre-HIV medication that is similar to Truvada. It also contains tenofovir alafenamide and emtricitabine. Descovy is taken once daily as a pill and works by blocking the same enzyme, reverse transcriptase, as Truvada. Studies have shown that Descovy is as effective as Truvada in preventing HIV infection. It is often prescribed to individuals who may have a higher risk of kidney or bone-related side effects from Truvada.

3. Tivicay

Tivicay is an integrase strand transfer inhibitor (INSTI) that is sometimes used as a pre-HIV medication. It contains the drug dolutegravir and is taken as a pill once daily. Tivicay works by blocking the integrase enzyme, which is required for HIV to insert its genetic material into human cells. While Tivicay is not specifically approved as a pre-HIV medication, it has shown effectiveness in reducing the risk of HIV transmission. It is often used in combination with other antiretroviral drugs.

4. Isentress

Isentress is another INSTI medication commonly used in HIV treatment but can also be used as a pre-HIV medication. It contains the drug raltegravir and is taken as a pill twice daily. Isentress works by blocking the integrase enzyme, similar to Tivicay. Studies have shown that Isentress is effective in reducing the risk of HIV transmission when taken consistently. It is often used in combination with other antiretroviral drugs as part of a comprehensive HIV prevention strategy.