What is the role of Valbenazine in managing Tardive Dyskinesia?

Tardive Dyskinesia (TD) is a neurological disorder characterized by repetitive and involuntary movements of the face, tongue, and other body parts. It is often caused by long-term use of antipsychotic medications, especially the first generation ones. Valbenazine, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of TD. This article will explore the role of Valbenazine in managing Tardive Dyskinesia and its effectiveness in improving symptoms.

What is the role of Valbenazine in managing Tardive Dyskinesia?

What is Valbenazine?

Valbenazine, also known by its brand name Ingrezza, is a medication used for the treatment of Tardive Dyskinesia. It works by inhibiting the reuptake of dopamine into vesicles within the presynaptic neuron, thus reducing the amount of dopamine available for release. Valbenazine specifically targets the vesicular monoamine transporter 2 (VMAT2), which is responsible for packaging dopamine into vesicles. By blocking VMAT2, Valbenazine helps regulate dopamine levels in the brain, which can improve the symptoms of Tardive Dyskinesia.

Effectiveness of Valbenazine in Managing Tardive Dyskinesia

Numerous clinical trials have been conducted to evaluate the effectiveness of Valbenazine in managing Tardive Dyskinesia. These studies have shown that Valbenazine can significantly reduce the severity and frequency of abnormal involuntary movements associated with TD. In a randomized, double-blind, placebo-controlled trial, patients treated with Valbenazine experienced a greater improvement in TD symptoms compared to those who received a placebo. The results of these trials indicate that Valbenazine is an effective treatment option for individuals with Tardive Dyskinesia.

Safety and Side Effects of Valbenazine

Like any medication, Valbenazine can cause side effects. The most common side effects reported in clinical trials include sleepiness, dry mouth, and an abnormal heartbeat. It is important for healthcare providers to carefully monitor patients taking Valbenazine and adjust the dosage if necessary. Additionally, Valbenazine should not be taken in combination with certain medications, as it may interact and cause adverse effects. Patients should inform their healthcare providers about any other medications they are taking to ensure safe and effective treatment with Valbenazine.

Conclusion

Valbenazine, a selective VMAT2 inhibitor, has emerged as an effective treatment option for individuals with Tardive Dyskinesia. By regulating dopamine levels in the brain, Valbenazine can reduce the severity and frequency of abnormal involuntary movements associated with TD. However, it is important to consider the potential side effects and interactions of Valbenazine, and patients should work closely with their healthcare providers for safe and effective management of Tardive Dyskinesia.

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